Structure of PDB 5x4k Chain A

Receptor sequence

>5x4kA (length=471) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence]

SHMDKEGFLNKVREAVDVVKLHIELGHTIRIISHRDADGITSAAILAKAL
GREGASFHISIVKQVSEDLLRELKDEDYKIFIFSALGSGSLSLIKEYLKE
KTVIILDHHPPENVKLEEKHILVNPVQFGANSVRDLSGSGVTYFFARELN
EKNRDLAYIAIVGAVGDMQENDGVFHGMNLDIIEDGKSLGILEVKKELRL
FGRETRPLYQMLAYATNPEIPEVTGDERKAIEWLKNKGFNPEKKYWELSE
EEKKKLHDFLIIHMIKHGAGKEDIDRLIGDVVISPLYPEGDPRHEAREFA
TLLNATGRLNLGNLGVAVCLGDEEAFRKALKMVEDYKREQIEARKWLLQN
WNSEVWEGDHVYVLYVGKSIRDTLVGIAASMAINAGLADPEKPVIVFADT
DEDPNLLKGSARTTERALAKGYNLGEALRKAAELVNGEGGGHAIAAGIRI
PRARLAEFRKLIDKILGEQVS

3D structure

PDB

5x4k The crystal structure of Pyrococcus furiosus RecJ implicates it as an ancestor of eukaryotic Cdc45.

Chain

Resolution

1.749 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	D36 H106 D165	D38 H108 D167
BS02	ZN	A	H32 D34	H34 D36
BS03	C5P	A	H107 K406 S408 R410 G437 G438 G439 A444 G445	H109 K408 S410 R412 G439 G440 G441 A446 G447
BS04	C5P	A	H32 H106 H107 D165 M166 N169 R410 H440 I442 A443	H34 H108 H109 D167 M168 N171 R412 H442 I444 A445
BS05	C5P	A	T214 Q338 I375 S378	T216 Q340 I377 S380

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:5x4k, PDBe:5x4k, PDBj:5x4k
PDBsum	5x4k
PubMed	30053256
UniProt	Q8TZE0

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