Structure of PDB 5x49 Chain A

Receptor sequence
>5x49A (length=441) Species: 9606 (Homo sapiens) [Search protein sequence]
LLRPGEVTPGLSQVEYALRRHKLMSLIQKETDQTVVVLSNPTYYMSNDIP
YTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSREL
WDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHA
QLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLT
SQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAGGNRSNT
LHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYE
AVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFK
AARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKD
APEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQIC
3D structure
PDB5x49 Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes.
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D110 H314 D331 D342 H420 H424 H431 E451 Y455 R473 E475
Catalytic site (residue number reindexed from 1) D48 H252 D269 D280 H358 H362 H369 E389 Y393 R411 E413
Enzyme Commision number 3.4.11.9: Xaa-Pro aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D342 H424 T449 E451 E475 D280 H362 T387 E389 E413
BS02 MN A Y300 D331 D342 E475 Y238 D269 D280 E413
BS03 01B A Y300 H314 D331 D342 H424 H431 E451 E475 Y238 H252 D269 D280 H362 H369 E389 E413
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0030145 manganese ion binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0003094 glomerular filtration
GO:0006508 proteolysis
GO:0016485 protein processing
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5x49, PDBe:5x49, PDBj:5x49
PDBsum5x49
PubMed28476889
UniProtQ9NQH7|XPP3_HUMAN Xaa-Pro aminopeptidase 3 (Gene Name=XPNPEP3)

[Back to BioLiP]