Structure of PDB 5wzy Chain A

Receptor sequence
>5wzyA (length=324) Species: 7955 (Danio rerio) [Search protein sequence]
RFTQALVIAYVIGYVCVYNKGYQDTDTVLSSVTTKVKGIALTKTSELGER
IWDVADYIIPPQEDGSFFVLTNMIITTNQTQSKCAENPTPASTCTSHRDC
KRGFNDARGDGVRTGRCVSYSASVKTCEVLSWCPLEKIVDPPNPPLLADA
ERFTVLIKNNIRYPKFNFNKRNILPNINSSYLTHCVFSRKTDPDCPIFRL
GDIVGEAEEDFQIMAVRGGVMGVQIRWDCDLDMPQSWCVPRYTFRRLDNK
DPDNNVAPGYNFRFAKYYKNSDGTETRTLIKGYGIRFDVMVFGQAGKFNI
IPTLLNIGAGLALLGLVNVICDWI
3D structure
PDB5wzy Structural insights into the nucleotide base specificity of P2X receptors
ChainA
Resolution2.799 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A H219 D227 H184 D192
BS02 CTP A R143 N296 R298 K316 R108 N261 R263 K281
Gene Ontology
Molecular Function
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellularly ATP-gated monoatomic cation channel activity
GO:0005216 monoatomic ion channel activity
GO:0005524 ATP binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0033198 response to ATP
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5wzy, PDBe:5wzy, PDBj:5wzy
PDBsum5wzy
PubMed28332633
UniProtF8W463|P2X4A_DANRE P2X purinoceptor 4a (Gene Name=p2rx4a)

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