Structure of PDB 5wzx Chain A

Receptor sequence
>5wzxA (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
ELTPDQQTLLHFIMDSYNKQRMPQEITNKLILTEMATNHVQVLVEFTKKL
PGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPLEERIRNSGISDEY
ITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPL
LDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKF
TPLLCEIWDV
3D structure
PDB5wzx Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V312 K316 H326 Q329 I330 L477 E480 V44 K48 H58 Q61 I62 L203 E206
BS02 7VX A M341 F342 S345 S368 F379 M463 W467 W482 M73 F74 S77 S94 F105 M189 W193 W208
BS03 BU3 A L353 P354 L361 L85 P86 L87
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5wzx, PDBe:5wzx, PDBj:5wzx
PDBsum5wzx
PubMed29162643
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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