Structure of PDB 5wz3 Chain A

Receptor sequence
>5wz3A (length=565) Species: 64320 (Zika virus) [Search protein sequence]
HMKIIGNRIERIRSEHAETWFFDENHPYRTWAYHGSYEAPLINGVVRLLS
KPWDVVTGVTGITTPYGQQRVFKEKVDTRVPDPQEGTRQVMSMVSSWLWK
ELGKHKRPRVCTKEEFINKVRSEAVNDPRFWALVDKEREHHLRGECQSCV
YNMWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVEGLGLQRLGYVLEE
MSRIPGGRMYADDTAGWDTRISRFDLENEALITNQMEKGHRALALAIIKY
TYQNKVVKVLRPAEKGKTVMDIISRQDQRGSGQVVTYALNTFTNLVVQLI
RNMEAEEVLEMQDLWLLRRSEKVTNWLQSNGWDRLKRMAVSGDDCVVKPI
DDRFAHALRFLNDMGKVRKDTQEWKPSTGWDNWEEVPFCSHHFNKLHLKD
GRSIVVPCRHQDELIGRARVSPGAGWSIRETACLAKSYAQMWQLLYFHRR
DLRLMANAICSSVPVDWVPTGRTTWSIHGKGEWMTTEDMLVVWNRVWIEE
NDHMEDKTPVTKWTDIPYLGKREDLWCGSLIGHRPRTTWAENIKNTVNMV
RRIIGDEEKYMDYLS
3D structure
PDB5wz3 The crystal structure of Zika virus NS5 reveals conserved drug targets.
ChainA
Resolution1.804 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H714 C730 C849 H392 C408 C527
BS02 ZN A E439 H443 C448 C451 E137 H141 C146 C149
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5wz3, PDBe:5wz3, PDBj:5wz3
PDBsum5wz3
PubMed28254839
UniProtA0A109PRQ3

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