Structure of PDB 5wy1 Chain A

Receptor sequence
>5wy1A (length=1140) Species: 10090 (Mus musculus) [Search protein sequence]
PKCPECGQHLDDPNLKYQQHPEDAVDEPQMLTSEKLSYEDSPMHRFTSFS
VYCSRGHLCPVDTGLIEKNVELYFSGCAKAIHDENPSMEGGINGKNLGPI
NQWWLSGFDGGEKVLIGFSTAFAEYILMEPSKEYEPIFGLMQEKIYISKI
VVEFLQNNPDAVYEDLINKIETTVPPSTINVNRFTEDSLLRHAQFVVSQV
ESYDEAKDDDETPIFLSPCMRALIHLAGVSLGQRRATRAPTKATTTKLVY
QIFDTFFSEQIEKRRRCGVCEVCQQPACLKRRCPNLAVKEADDDEEADDE
MPSPKKLHQGKKKKQNKDRISWLGQPMKIERTYYQKVSIDEEMLEVGDCV
SVIPDDSSKPLYLARVTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLE
LFLVGECENMQLSYIHSKVKVIYKAPSENWAMEGGKTYFFQLWYNQEYAR
FESPPKTQPTEDNKHKFCLSCIRLAELRQKEMPKVLEQIEEVDGRVYCSS
ITKNGVVYRLGDSVYLPPEAFTFNIKVKKDPVNETLYPEHYRKYSLDAPE
PYRIGRIKEIHCGKKKGKVNEADIKLRLYKFYRPENTHRSYNGSYHTDIN
MLYWSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEAYN
SKTKNFEDPPNHARSKLPKLRTLDVFSGCGGLSEGFHQAGISETLWAIEM
WDPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQKGDVEM
LCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVR
NFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAA
PGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRD
TMSDLPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICKDMSP
LVAARMRHIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNGYSST
GALRGVCSCAEGKACDPESRQFSTLIPWCLPHAGNRHNHWAGLYGRLEWD
GFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYRFFGNIL
DRHRQVGNAVPPPLAKAIGLEIKLCLLSSARESASAAVKA
3D structure
PDB5wy1 Conserved threonine 1505 in the catalytic domain stabilizes mouse DNA methyltransferase 1
ChainA
Resolution3.27 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C1229 E1269 R1313 R1315
Catalytic site (residue number reindexed from 1) C757 E797 R841 R843
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C359 C362 C420 H424 C3 C6 C53 H57
BS02 ZN A C656 C659 C662 C694 C267 C270 C273 C283
BS03 ZN A H796 C823 C897 C900 H380 C407 C468 C471
BS04 ZN A C1479 C1481 C1487 H1504 C1007 C1009 C1015 H1032
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006346 DNA methylation-dependent heterochromatin formation
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5wy1, PDBe:5wy1, PDBj:5wy1
PDBsum5wy1
PubMed28369487
UniProtP13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)

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