Structure of PDB 5wwx Chain A

Receptor sequence
>5wwxA (length=84) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHHHHMSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVT
PSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTG
3D structure
PDB5wwx The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A H316 V338 G339 L340 V342 G343 K345 G346 I349 K350 Q353 I360 V361 T362 P363 R365 H4 V26 G27 L28 V30 G31 K33 G34 I37 K38 Q41 I48 V49 T50 P51 R53
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:5wwx, PDBe:5wwx, PDBj:5wwx
PDBsum5wwx
PubMed28808060
UniProtQ5U5Q3|MEX3C_HUMAN RNA-binding E3 ubiquitin-protein ligase MEX3C (Gene Name=MEX3C)

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