Structure of PDB 5www Chain A

Receptor sequence
>5wwwA (length=94) Species: 9606 (Homo sapiens) [Search protein sequence]
GHHHHHHMQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKT
NTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRAS
3D structure
PDB5www The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity
ChainA
Resolution1.798 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A S241 E242 V244 A245 E246 G249 R250 Q251 G252 K254 I255 K256 R259 I266 K267 T268 P269 R271 H299 F300 I303 R304 S29 E30 V32 A33 E34 G37 R38 Q39 G40 K42 I43 K44 R47 I54 K55 T56 P57 R59 H87 F88 I91 R92
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:5www, PDBe:5www, PDBj:5www
PDBsum5www
PubMed28808060
UniProtQ5U5Q3|MEX3C_HUMAN RNA-binding E3 ubiquitin-protein ligase MEX3C (Gene Name=MEX3C)

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