Structure of PDB 5wwp Chain A

Receptor sequence
>5wwpA (length=515) Species: 1235996 (Human betacoronavirus 2c EMC/2012) [Search protein sequence]
PAVGSCVVCHSQTSLRCGTCIRRPFLCCKCCYDHVIATPHKMVLSVSPYV
CNAPGCGVSDVTKLYLGGMSYFCVDHRPVCSFPLCANGLVFGLYKNMCTG
SPSIVEFNRLATCDWTESGDYTLANTTTEPLKLFAAETLRATEEASKSVA
TLTAPTIVNQERYVKITGLYPTITVPEEFASHVANFQKSGYSKYVTVQGP
PGTGKSHFAIGLAIYYPTARVVYTACSHAAVDALCEKAFKYLNIAKCSRI
IPAKARVECYDRFKVNETNSQYLFSTINALPETSADILVVDEVSMCTNYD
LSIINARIKAKHIVYVGDPAQLPAPRTLLTRGTLEPENFNSVTRLMCNLG
PDIFLSMCYRCPKEIVSTVSALVYNNKLLAKKELSGQCFKILYKGNVTHD
ASSAINRPQLTFVKNFITANPAWSKAVFISPYNSQNAVSRSMLGLTTQTV
DSSQGSEYQYVIFCQTADTAHANNINRFNVAITRAQKGILCVMTSQALFE
SLEFTELSFTNYKLQ
3D structure
PDB5wwp Crystal structure of Middle East respiratory syndrome coronavirus helicase
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C5 C8 C26 C29 C6 C9 C27 C30
BS02 ZN A C16 C19 H33 C17 C20 H34
BS03 ZN A C50 C55 C72 H75 C51 C56 C73 H76
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5wwp, PDBe:5wwp, PDBj:5wwp
PDBsum5wwp
PubMed28651017
UniProtK0BWD0

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