Structure of PDB 5wuu Chain A

Receptor sequence
>5wuuA (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPT
3D structure
PDB5wuu Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.
ChainA
Resolution1.724 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7UU A W81 P82 L92 L94 N140 D145 I146 W39 P40 L50 L52 N98 D103 I104 MOAD: ic50=0.81uM
PDBbind-CN: -logKd/Ki=6.09,IC50=0.81uM
BindingDB: IC50=810nM
External links
PDB RCSB:5wuu, PDBe:5wuu, PDBj:5wuu
PDBsum5wuu
PubMed28347667
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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