Structure of PDB 5wu4 Chain A

Receptor sequence
>5wu4A (length=485) Species: 9606 (Homo sapiens) [Search protein sequence]
DSHQLAKALAEAADVGAQMIKLVGLRELSEAERQLRSLVVALMQEVFTEF
FPGCVVHPFGSSINSFDVHGCDLDLFLDLETPKEEKAEGAAMLELVGSIL
RGCVPGVYRVQTVPSARRPVVKFAHRPSGLHGDVSLSNRLALHNSRFLSL
CSELDGRVRPLVYTLRAWAQGRGLSGSGPLLSNYALTLLVIYFLQTRDPP
VLPTVSQLTQKAGEGEQVEVDGWDCSFPRDASRLEPSINVEPLSSLLAQF
FSAVSSWDLRGSLLSLREGQALPVAGGLPSNLWEGLRLGPLNLQDPFDLS
HNVAANVTSRVAGRLQNCCRAAANYCRSLQYQRRSSRGRDWGLLPLLQPS
SPSSLLSATPIPLPLAPFTQLTAALVQVFREALGCHIEQSASWRCALWHR
VWQGRRRARRRLQQQTKEGGWLATEAQVTQELKTEPLLSFVASVSPADRM
LTVTPLQDPQGLFPDLHHFLQVFLPQAIRHLKLEH
3D structure
PDB5wu4 Crystal structures of U6 snRNA-specific terminal uridylyltransferase
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.52: RNA uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A S205 D218 Y432 H549 S61 D74 Y184 H301
BS02 MG A S205 D216 D218 S61 D72 D74
External links
PDB RCSB:5wu4, PDBe:5wu4, PDBj:5wu4
PDBsum5wu4
PubMed28589955
UniProtQ9H6E5|STPAP_HUMAN Speckle targeted PIP5K1A-regulated poly(A) polymerase (Gene Name=TUT1)

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