Structure of PDB 5wrs Chain A

Receptor sequence
>5wrsA (length=431) Species: 9606 (Homo sapiens) [Search protein sequence]
SSKLQALFAHPLYNVPEEPPLLGAEDSLLASQEALRYYRRKVARWNRRHK
MYREQMDPPLQLRLEASWVQFHLGINRHGLYSRSSPVVSKLLQDMRHFPT
ISADYSQDEKALLGACDCTQIVKSGVHLKLVLRFSDFGKAMFKPMRQQRD
EETPVDFFYFIDFQRHNAEIAAFHLDRILDFRRVPPTVGRIVNVTKEILE
VTKNEILQSVFFVSPASNVCFFAKCPYMCKTEYAVCGKPHLLEGSLSAFL
PSLNLAPRLSVPNPWIRSYTLAGKEEWEVNPLYCDTVKQIYPYNNSQRLL
NVIDMAIFDFLIGNMDRHHYEMFTKFGDDGFLIHLDNARGFGRHSHDEIS
ILSPLSQCCMIKKKTLLHLQLLAQADYRLSDVMRESLLEDQLSPVLTEPH
LLALDRRLQTILRTVEGCIVAHGQQSVIVDG
3D structure
PDB5wrs Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A Y125 K129 K233 P279 S341 A342 F343 L344 S346 L347 R352 Y37 K41 K139 P185 S247 A248 F249 L250 S252 L253 R258 PDBbind-CN: -logKd/Ki=5.52,Kd=3uM
External links
PDB RCSB:5wrs, PDBe:5wrs, PDBj:5wrs
PDBsum5wrs
PubMed28432788
UniProtQ96MK3|FA20A_HUMAN Pseudokinase FAM20A (Gene Name=FAM20A)

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