Structure of PDB 5wrm Chain A

Receptor sequence
>5wrmA (length=259) Species: 10116 (Rattus norvegicus) [Search protein sequence]
IGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSG
MPECKFGMNDKKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMR
YRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPT
PLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTN
DKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIG
RSGIYETRC
3D structure
PDB5wrm IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
ChainA
Resolution2.597 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F174 D176 K420 W421 V422 R423 F16 D18 K244 W245 V246 R247
Gene Ontology
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0030131 clathrin adaptor complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5wrm, PDBe:5wrm, PDBj:5wrm
PDBsum5wrm
PubMed29661273
UniProtP84092|AP2M1_RAT AP-2 complex subunit mu (Gene Name=Ap2m1)

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