Structure of PDB 5wpb Chain A

Receptor sequence
>5wpbA (length=101) Species: 9606 (Homo sapiens) [Search protein sequence]
GSPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRY
INGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNK
F
3D structure
PDB5wpb Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1145 C1148 H1164 H1170 F1207 C39 C42 H58 H64 F101
BS02 ZN A C1133 C1136 C1153 H1160 C27 C30 C47 H54
BS03 ZN A C1113 H1115 C1183 C1186 C7 H9 C77 C80
BS04 B8P A W1143 G1154 R1155 S1175 D1178 W1182 Y1184 Y1189 W37 G48 R49 S69 D72 W76 Y78 Y83 PDBbind-CN: -logKd/Ki=3.57,IC50=270uM
BindingDB: IC50=270000nM
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5wpb, PDBe:5wpb, PDBj:5wpb
PDBsum5wpb
PubMed29019676
UniProtQ9UBN7|HDAC6_HUMAN Histone deacetylase 6 (Gene Name=HDAC6)

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