Structure of PDB 5wnl Chain A

Receptor sequence
>5wnlA (length=262) Species: 10090 (Mus musculus) [Search protein sequence]
ALGLLRTFDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPVDDRE
RMELLEEAKKMEMAKFRYILPVYGICQEPVGLVMEYMETGSLEKLLASEP
LPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDF
GLAKCFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADE
KNILHIMMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTF
QEITSETEDLCE
3D structure
PDB5wnl Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N143 A147 N148 D161
Catalytic site (residue number reindexed from 1) N131 A135 N136 D149
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A V28 G29 A49 K51 M96 E97 Y98 M99 G102 A147 L150 V19 G20 A40 K42 M84 E85 Y86 M87 G90 A135 L138
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5wnl, PDBe:5wnl, PDBj:5wnl
PDBsum5wnl
PubMed29706531
UniProtQ9ERK0|RIPK4_MOUSE Receptor-interacting serine/threonine-protein kinase 4 (Gene Name=Ripk4)

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