Structure of PDB 5wni Chain A

Receptor sequence
>5wniA (length=263) Species: 10090 (Mus musculus) [Search protein sequence]
WALGLLRTFDAGEFAGWEKVGSQVYKVRHVHWKTWLAIKCSPSLHVDDRE
RMELLEEAKKMEMAKFRYILPVYGICQEPVGLVMEYMETGSLEKLLASEP
LPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDF
GLAKCNFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFAD
EKNILHIMMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPT
FQEITSETEDLCE
3D structure
PDB5wni Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.
ChainA
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N143 A147 N148 D161
Catalytic site (residue number reindexed from 1) N131 A135 N136 D149
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N148 D161 N136 D149
BS02 ATP A V36 A49 K51 M96 Y98 M99 A147 L150 D161 V24 A37 K39 M84 Y86 M87 A135 L138 D149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5wni, PDBe:5wni, PDBj:5wni
PDBsum5wni
PubMed29706531
UniProtQ9ERK0|RIPK4_MOUSE Receptor-interacting serine/threonine-protein kinase 4 (Gene Name=Ripk4)

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