Structure of PDB 5wmt Chain A

Receptor sequence
>5wmtA (length=210) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
EKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDE
NALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSQ
STSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADP
RGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKT
KTVWDWELMN
3D structure
PDB5wmt Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
ChainA
Resolution2.748 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9QY A N107 D149 M154 N162 F195 T245 I247 N34 D76 M81 N89 F109 T159 I161 PDBbind-CN: -logKd/Ki=5.86,Kd=1.38uM
BindingDB: Ki=440nM,IC50=1100nM,Kd=1380nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:5wmt, PDBe:5wmt, PDBj:5wmt
PDBsum5wmt
PubMed29528635
UniProtP41148|ENPL_CANLF Endoplasmin (Gene Name=HSP90B1)

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