Structure of PDB 5wml Chain A

Receptor sequence
>5wmlA (length=404) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
MSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAE
AGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAK
QSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFL
LDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLV
LSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSAAFAMTGWRLGYLA
GPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYR
ERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSS
LALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPL
RATV
3D structure
PDB5wml Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis.
ChainA
Resolution2.103 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.1: aspartate transaminase.
2.6.1.78: aspartate--prephenate aminotransferase.
2.6.1.79: glutamate--prephenate aminotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PMP A G167 A168 K169 L172 W193 N243 D272 Y275 S305 R314 G98 A99 K100 L103 W124 N174 D203 Y206 S236 R245
BS02 GLU A T84 M85 A106 G107 K169 W193 Y395 R445 T15 M16 A37 G38 K100 W124 Y326 R376
Gene Ontology
Molecular Function
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0033853 aspartate-prephenate aminotransferase activity
GO:0033854 glutamate-prephenate aminotransferase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0008652 amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0009094 L-phenylalanine biosynthetic process
GO:0009095 aromatic amino acid family biosynthetic process, prephenate pathway
GO:0009793 embryo development ending in seed dormancy
Cellular Component
GO:0005829 cytosol
GO:0009507 chloroplast
GO:0009570 chloroplast stroma

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Molecular Function
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Cellular Component
External links
PDB RCSB:5wml, PDBe:5wml, PDBj:5wml
PDBsum5wml
PubMed29405514
UniProtQ9SIE1|PAT_ARATH Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase (Gene Name=PAT)

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