Structure of PDB 5wmd Chain A

Receptor sequence
>5wmdA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
GMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPAYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5wmd BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.
ChainA
Resolution1.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6JE A W81 P82 L92 L94 N140 I146 M149 W40 P41 L51 L53 N99 I105 M108 BindingDB: IC50=92nM,Ki=11nM
External links
PDB RCSB:5wmd, PDBe:5wmd, PDBj:5wmd
PDBsum5wmd
PubMed29386193
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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