Structure of PDB 5wm2 Chain A

Receptor sequence
>5wm2A (length=536) Species: 1649596 (Streptomyces gandocaensis) [Search protein sequence]
SHMLDGWVPWPESFARRYRAAGYWEGRPLDRLLRERAAADPDRIALVDAA
GDRWTYAELDRHADRQAAGLRRLGIGAGDRVVVQLPNTDAFVVLFFALLR
AGAVPVLTLPAHRESEIVHVAETAGATAYVIPDVLDGFDHRALARAARKA
VPSIEHVLVAGEAAEFTALADVDAAPVPLAEPDPGDVALLLLSGGTTGKP
KLIPRTHDDYTYNVRASAEVCGFDSDTVYLVVLPTAHNFALACPGLLGTL
MVGGTVVLAPTPSPEDAFELIEREKVTATAVVPPVALLWLDAVEWEDADL
SSLRLLQVGGSKLGAEPAARVRPALGCTLQQVFGMAEGLLNYTRLDDPSD
LVIQTQGRPLSPDDEIRVVDEDGRDVAPGETGELLTRGPYTLRGYYRAPE
HNARTFSDDGFYRTGDLVRVLPSGHLVVEGRAKDQINRGGDKISAEELEN
HIMAHPGVHDAAVVGMPDATMGERTCACLVPRAGRSAPAQRELAAFLTDR
GVAAYKLPDRVEVMDAFPRTSVGKTDKKELGRRIAG
3D structure
PDB5wm2 A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity of the Cahuitamycin Starter Unit-Activating Enzyme CahJ.
ChainA
Resolution1.548 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S211 N231 H255 A354 E355 N455 K460 K542
Catalytic site (residue number reindexed from 1) S193 N213 H237 A336 E337 N437 K442 K524
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A G328 S329 K330 V350 F351 G352 M353 A354 E355 D434 V446 K451 K460 G310 S311 K312 V332 F333 G334 M335 A336 E337 D416 V428 K433 K442
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0016874 ligase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5wm2, PDBe:5wm2, PDBj:5wm2
PDBsum5wm2
PubMed29742306
UniProtA0A140DJY3

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