Structure of PDB 5wly Chain A

Receptor sequence
>5wlyA (length=220) Species: 562 (Escherichia coli) [Search protein sequence]
ATLFIADLHLCVAAPAITAGFLRFLAGEARKADALYILGDLFEAWIGDDD
PNPLHRKMAAAIKAVSDSGVPCYFIHGNRDFLLGKRFARESGMTLLPEEK
VLELYGRRVLIMHGDTLCTDKVHKPWLQTLHSALPSHVRKRIAARMRANS
TDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHT
EGSMVKVTADDVELIHFPFL
3D structure
PDB5wly The substrate-binding cap of the UDP-diacylglucosamine pyrophosphatase LpxH is highly flexible, enabling facile substrate binding and product release.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.54: UDP-2,3-diacylglucosamine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D41 N79 H114 H195 D40 N78 H113 H174
BS02 MN A D8 H10 D41 H197 D7 H9 D40 H176
Gene Ontology
Molecular Function
GO:0008758 UDP-2,3-diacylglucosamine hydrolase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0009245 lipid A biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0019897 extrinsic component of plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5wly, PDBe:5wly, PDBj:5wly
PDBsum5wly
PubMed29626094
UniProtP43341|LPXH_ECOLI UDP-2,3-diacylglucosamine hydrolase (Gene Name=lpxH)

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