Structure of PDB 5wlb Chain A

Receptor sequence
>5wlbA (length=159) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAVGVGKSALTIQLIQNHFVDDSYRKQVVIDGETCLLDILD
TAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSE
DVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFY
TLVREIRKH
3D structure
PDB5wlb Exceptionally high-affinity Ras binders that remodel its effector domain.
ChainA
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A V12 G13 V14 G15 K16 S17 A18 F28 D30 G60 N116 K117 D119 S145 A146 V12 G13 V14 G15 K16 S17 A18 F28 D30 G53 N109 K110 D112 S138 A139
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5wlb, PDBe:5wlb, PDBj:5wlb
PDBsum5wlb
PubMed29282294
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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