Structure of PDB 5wkk Chain A

Receptor sequence
>5wkkA (length=301) Species: 1335626 (Middle East respiratory syndrome-related coronavirus) [Search protein sequence]
HHSGLVKMSHPSGDVEACMVQVTCGMTLNGLWLDNTVWCPRHVMCPADQL
SDPNYDALLISMTNHSFSVQKHANLRVVGHAMQGTLLKLTVDVANPSTPA
YTFTTVKPGAAFSVLACYNGRPTGTFTVVMRPNYTIKGSFLCGSCGSVGY
TKEGSVINFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTDKYC
SVNVVAWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVGTQSVDM
LAVKTGVAIEQLLYAIQQLYTGFQGKQILGSTMLEDEFTPEDVNMQIMGV
V
3D structure
PDB5wkk Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AW4 A F143 C145 C148 H166 Q167 M168 E169 Q192 V193 H194 F140 C142 C145 H163 Q164 M165 E166 Q189 V190 H191
BS02 B3G A F143 C145 C148 H166 Q167 M168 E169 Q192 V193 H194 F140 C142 C145 H163 Q164 M165 E166 Q189 V190 H191
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5wkk, PDBe:5wkk, PDBj:5wkk
PDBsum5wkk
PubMed29544147
UniProtK9N638|R1A_MERS1 Replicase polyprotein 1a (Gene Name=1a)

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