Structure of PDB 5wh5 Chain A

Receptor sequence
>5wh5A (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]
TEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTF
KIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVF
TDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA
VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKT
MVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDR
IMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWA
DLVHPDAQDILDTLEDNREWYQSTIP
3D structure
PDB5wh5 Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R91 A Y159 N321 Y329 W332 T333 I336 M357 S368 Q369 F372 Y74 N236 Y244 W247 T248 I251 M272 S283 Q284 F287 PDBbind-CN: -logKd/Ki=7.19,IC50=65nM
BS02 ZN A H164 H200 D201 D318 H79 H115 D116 D233
BS03 MG A D151 Y153 D66 Y68
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5wh5, PDBe:5wh5, PDBj:5wh5
PDBsum5wh5
PubMed29975048
UniProtQ08499|PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (Gene Name=PDE4D)

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