Structure of PDB 5wgq Chain A

Receptor sequence
>5wgqA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLTADQMVSALLDAEPPILYSEYDPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLL
DRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYL
KSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRH
MSNKGMEHLYSMKCKNVVPLSDLLLEMLDAH
3D structure
PDB5wgq A "cross-stitched" peptide with improved helicity and proteolytic stability.
ChainA
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 L372 V376 E380 E542 I48 L62 V66 E70 E226
BS02 EST A L346 E353 H524 L525 L36 E43 H208 L209 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:5wgq, PDBe:5wgq, PDBj:5wgq
PDBsum5wgq
PubMed29725689
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

[Back to BioLiP]