Structure of PDB 5wgd Chain A

Receptor sequence
>5wgdA (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHM
INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPN
LLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSG
VYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN
KGMEHLYSMKCKNVVPLSDLLLEMLDAH
3D structure
PDB5wgd A "cross-stitched" peptide with improved helicity and proteolytic stability.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 L372 V376 E380 E542 I51 L65 V69 E73 E223
BS02 EST A E353 H524 L525 E46 H205 L206 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:5wgd, PDBe:5wgd, PDBj:5wgd
PDBsum5wgd
PubMed29725689
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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