Structure of PDB 5wfz Chain A

Receptor sequence

>5wfzA (length=179) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1)))

GSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFM
YSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENR
FIDIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEE
SRARIKTRLFTIRQEMASRSLWDSFRQSE

3D structure

• PDB: 5wfz Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease.
• Chain: A
• Resolution: 2.35 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	H41 D108 D119 I120	H44 D92 D103 I104
BS02	MN	A	E80 D108	E64 D92
BS03	KU0	A	K34 I38 H41 F105 L106 D108 D119 K134	K37 I41 H44 F89 L90 D92 D103 K118	MOAD: Ki<0.01uM PDBbind-CN: -logKd/Ki=8.00,Ki<0.01uM

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:5wfz, PDBe:5wfz, PDBj:5wfz
• PDBsum: 5wfz
• PubMed: 29215062
• UniProt: C3W5S0