Structure of PDB 5wev Chain A

Receptor sequence
>5wevA (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
SGAFEDRDPTQFEERHLKFLQQLGKGSVEMCRYDPLQDNTGEVVAVKKLQ
HSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYG
SLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE
NENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVAS
DVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNN
GRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNM
3D structure
PDB5wev Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
ChainA
Resolution1.854 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D976 A978 R980 N981 D994 S1016
Catalytic site (residue number reindexed from 1) D141 A143 R145 N146 D159 S181
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9ZS A L855 Y931 L932 G935 L983 L23 Y96 L97 G100 L148 MOAD: Ki=0.15uM
PDBbind-CN: -logKd/Ki=6.82,Ki=0.15uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5wev, PDBe:5wev, PDBj:5wev
PDBsum5wev
PubMed28830649
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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