Structure of PDB 5wej Chain A

Receptor sequence
>5wejA (length=172) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
APPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIAIH
QAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAVR
MGAIASMRIQRLVHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDW
VVCGVHAAATKSGNTVVCAVQA
3D structure
PDB5wej Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V45 A H30 I109 T134 C139 H157 A158 A159 A160 H30 I109 T133 C138 H156 A157 A158 A159 PDBbind-CN: -logKd/Ki=4.82,IC50=15.3uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5wej, PDBe:5wej, PDBj:5wej
PDBsum5wej
PubMed29227928
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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