Structure of PDB 5we8 Chain A

Receptor sequence
>5we8A (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
TKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLT
KSERQRFKEEAEMLKGLQHPNIVRFYDSWESTCIVLVTELMTSGTLKTYL
KRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGS
VKIGDLGLATLKRADFAKSVIGTPEFMAPEMYAAAYDESVDVYAFGMCML
EMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQN
KDERYSIKDLLNHAFFQEET
3D structure
PDB5we8 Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.
ChainA
Resolution2.006 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D349 K351 D353 N354 D368 K375 T386
Catalytic site (residue number reindexed from 1) D136 K138 D140 N141 D155 K162 T173
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A N354 D368 N141 D155
BS02 ANP A G228 G230 K233 V235 A248 L303 M304 K351 G20 G22 K25 V27 A40 L90 M91 K138
BS03 A7Y A L252 F265 E268 L272 F283 L299 I345 D368 L369 G370 A372 L374 L44 F57 E60 L64 F75 L86 I132 D155 L156 G157 A159 L161 BindingDB: IC50=750nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5we8, PDBe:5we8, PDBj:5we8
PDBsum5we8
PubMed28771350
UniProtQ9H4A3|WNK1_HUMAN Serine/threonine-protein kinase WNK1 (Gene Name=WNK1)

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