Structure of PDB 5wdx Chain A

Receptor sequence
>5wdxA (length=642) [Search protein sequence]
GCVSIIGRLHVNQRASITAYAQQTRGLLGAIVVSMTGRDRTEQAGEVQIL
STVSQSFLGTTISGVLWTVYHGAGNKTLAGLRGPVTQMYSSAEGDLVGWP
SPPGTKSLEPCKCGAVDLYLVTRNADVIPARRRGDKRGALLSPRPISTLK
GSSGGPVLCPRGHVVGLFRAAVCSRGVAKSIDFIPVETLDVVTRSSDNST
PPAVPQTYQVGYLHAPTGSGKSTKVPVAYAAQGYKVLVLNPSVAATLGFG
AYLSKAHGINPNIRTGVRTVMTGEAITYSTYGKFLADGGCASGAYDIIIC
DECHAVDATSILGIGTVLDQAETAGVRLTVLATATPPGSVTTPHPDIEEV
GLGREGEIPFYGRAIPLSCIKGGRHLIFCHSKKKCDELAAALRGMGLNAV
AYYRGLDVSIIPAQGDVVVVATDALMTGYTGDFDSVIDCNVAVTQAVDFS
LDPTFTITTQTVPQDAVSRSQRRGRTGRGRQGTYRYVSTGERASGMFDSV
VLCECYDAGAAWYDLTPAETTVRLRAYFNTPGLPVCQDHLEFWEAVFTGL
THIDAHFLSQTKQAGENFAYLVAYQATVCARAKAPPPSWDAMWKCLARLK
PTLAGPTPLLYRLGPITNEVTLTHPGTKYIATCMQADLEVMT
3D structure
PDB5wdx NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA.
ChainA
Resolution2.23 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H71 D95 G151 S153
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C97 C145 H149 C111 C159 H163
BS02 MG A G207 G209 S211 G218 G220 S222
BS03 MG A K210 A323 K221 A334
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:5wdx, PDBe:5wdx, PDBj:5wdx
PDBsum5wdx
PubMed29070684
UniProtR9TEU1

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