Structure of PDB 5wdw Chain A

Receptor sequence

>5wdwA (length=180) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1)))

RGSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCF
MYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKEN
RFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDE
ESRARIKTRLFTIRQEMASRSLWDSFRQSE

3D structure

• PDB: 5wdw Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	H41 D108 E119 I120	H45 D93 E104 I105
BS02	MN	A	E80 D108	E65 D93
BS03	8KU	A	Y24 K34 A37 I38 H41 E80 D108	Y28 K38 A41 I42 H45 E65 D93	MOAD: Ki=0.29uM PDBbind-CN: -logKd/Ki=6.54,Ki=0.29uM

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:5wdw, PDBe:5wdw, PDBj:5wdw
• PDBsum: 5wdw
• PubMed: 29215062
• UniProt: C3W5S0