Structure of PDB 5wci Chain A

Receptor sequence
>5wciA (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
HSSGLVPRGSTKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYC
LKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVHEVDGKDHKIYCQNL
CLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNN
VACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRS
YWSWVLLENLRDFRGLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHV
ICVTPKLVEEHLKSAQYKPPITVDSVCLKWAPPK
3D structure
PDB5wci Human MYST histone acetyltransferase 1
ChainA
Resolution1.78 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C316 E350
Catalytic site (residue number reindexed from 1) C153 E187
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C210 C213 H226 C230 C47 C50 H63 C67
BS02 1VU A F270 L271 A315 C316 I317 L318 T319 Q324 R325 G327 G329 K330 E350 S354 L356 S360 S363 F107 L108 A152 C153 I154 L155 T156 Q161 R162 G164 G166 K167 E187 S191 L193 S197 S200
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5wci, PDBe:5wci, PDBj:5wci
PDBsum5wci
PubMed
UniProtQ9H7Z6|KAT8_HUMAN Histone acetyltransferase KAT8 (Gene Name=KAT8)

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