Structure of PDB 5wch Chain A

Receptor sequence
>5wchA (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
GFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGKTEDRAAYNIGV
LRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSL
VDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVD
IRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVL
AIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDGSTKY
RLVGVLVHSGQASGGHYYSYIIQRNGGRWYKFDDGDVTECKMDDDEEMKN
QCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTQDDELIRYIS
3D structure
PDB5wch Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1727 H1729 C1771 C1774 C134 H136 C178 C181
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5wch, PDBe:5wch, PDBj:5wch
PDBsum5wch
PubMed30914461
UniProtQ93008|USP9X_HUMAN Ubiquitin carboxyl-terminal hydrolase 9X (Gene Name=USP9X)

[Back to BioLiP]