Structure of PDB 5wc2 Chain A

Receptor sequence
>5wc2A (length=364) Species: 9606 (Homo sapiens) [Search protein sequence]
PTVHVEVHQRGSSTAKKEDINLSVRKLLNRHNIVFGDYTWTEFDEPFLTR
NVQSVSIIDLSACTVALHIFQLNEDIIAANHWVLPAAEFHGLWDSLVYDV
EVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALA
QKLTIRLSSRYRYGQLIEINSHSLVTKMFQKIQDLIDDKDALVFVLIDAV
ESLTAADAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADI
KQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENN
VSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALS
LAVDKQFEERKKLA
3D structure
PDB5wc2 Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing.
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A V140 G182 T183 G184 K185 T186 S187 I330 G385 R386 R389 V97 G139 T140 G141 K142 T143 S144 I265 G320 R321 R324
Gene Ontology
Molecular Function
GO:0003712 transcription coregulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
Biological Process
GO:0001556 oocyte maturation
GO:0006302 double-strand break repair
GO:0006366 transcription by RNA polymerase II
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0007130 synaptonemal complex assembly
GO:0007131 reciprocal meiotic recombination
GO:0007141 male meiosis I
GO:0007144 female meiosis I
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0030154 cell differentiation
GO:0048477 oogenesis
GO:0051321 meiotic cell cycle
GO:0051598 meiotic recombination checkpoint signaling
Cellular Component
GO:0001673 male germ cell nucleus
GO:0005634 nucleus
GO:0005694 chromosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5wc2, PDBe:5wc2, PDBj:5wc2
PDBsum5wc2
PubMed29208896
UniProtQ15645|PCH2_HUMAN Pachytene checkpoint protein 2 homolog (Gene Name=TRIP13)

[Back to BioLiP]