Structure of PDB 5wbn Chain A

Receptor sequence
>5wbnA (length=103) Species: 9606 (Homo sapiens) [Search protein sequence]
GSPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRY
INGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNK
FGE
3D structure
PDB5wbn Crystal structure of fragment 3-(3-Benzyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
ChainA
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1145 C1148 H1164 H1170 C39 C42 H58 H64
BS02 ZN A C1133 C1136 C1153 H1160 C27 C30 C47 H54
BS03 ZN A C1113 H1115 C1183 C1186 C7 H9 C77 C80
BS04 9ZV A W1143 R1155 W1182 Y1184 Y1189 W37 R49 W76 Y78 Y83 BindingDB: IC50=25000nM
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5wbn, PDBe:5wbn, PDBj:5wbn
PDBsum5wbn
PubMed
UniProtQ9UBN7|HDAC6_HUMAN Histone deacetylase 6 (Gene Name=HDAC6)

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