Structure of PDB 5wal Chain A

Receptor sequence
>5walA (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
TVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQ
HRSGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDY
LPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRNLAARNVLLDNDRLVKI
GDFGLAKAVPHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTL
YELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCP
AEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYR
3D structure
PDB5wal Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N1023 A1025 R1027 N1028 D1041 P1064
Catalytic site (residue number reindexed from 1) N134 A136 R138 N139 D152 P173
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9ZS A L903 G904 E905 V911 A928 I960 Y980 V981 P982 G984 L1030 L14 G15 E16 V22 A39 I71 Y91 V92 P93 G95 L141 MOAD: Ki=0.0017uM
PDBbind-CN: -logKd/Ki=8.77,Ki=0.0017uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5wal, PDBe:5wal, PDBj:5wal
PDBsum5wal
PubMed28830649
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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