Structure of PDB 5wa6 Chain A

Receptor sequence
>5wa6A (length=178) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1))) [Search protein sequence]
RGSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCF
MYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKEN
RFIEIGVTRREVHIYYLEKANKIEKTHIHIFSFTGEEMATKADYTLDEES
RARIKTRLFTIRQEMASRSLWDSFRQSE
3D structure
PDB5wa6 Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H45 D93 E104 I105
BS02 MN A E80 D108 E65 D93
BS03 KU7 A Y24 K34 I38 H41 E80 D108 E119 Y28 K38 I42 H45 E65 D93 E104 PDBbind-CN: -logKd/Ki=6.36,Ki=0.44uM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5wa6, PDBe:5wa6, PDBj:5wa6
PDBsum5wa6
PubMed29215062
UniProtC3W5S0

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