Structure of PDB 5w9c Chain A

Receptor sequence
>5w9cA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTADQMVSALLDAEPPILYSDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLL
DRNQGKSEMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFS
TLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHI
RHMSNKGMEHLYSMKSKNVVPSYDLLLEMLDAH
3D structure
PDB5w9c Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.
ChainA
Resolution1.802 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OHT A T347 A350 D351 E353 N532 V533 T37 A40 D41 E43 N218 V219 BindingDB: IC50=0.790000nM,EC50=10.3nM,Ki=5.7nM
External links
PDB RCSB:5w9c, PDBe:5w9c, PDBj:5w9c
PDBsum5w9c
PubMed29739819
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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