Structure of PDB 5w86 Chain A

Receptor sequence
>5w86A (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
PTIFEERHLKYISQLGKGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQR
DFQREIQILKALHSDFIVKYRGVSYLRLVMEYLPSGCLRDFLQRHRARLD
ASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAK
LLPLDKDYYVVSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKS
CSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLC
WAPSPQDRPSFSALGPQLDML
3D structure
PDB5w86 Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors.
ChainA
Resolution2.61 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D949 A951 R953 N954 D967
Catalytic site (residue number reindexed from 1) D127 A129 R131 N132 D145
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9YV A L828 A853 M902 E903 L905 G908 L956 L15 A37 M80 E81 L83 G86 L134 PDBbind-CN: -logKd/Ki=8.70,IC50=2nM
BindingDB: IC50=2.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5w86, PDBe:5w86, PDBj:5w86
PDBsum5w86
PubMed28947151
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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