Structure of PDB 5w7f Chain A

Receptor sequence
>5w7fA (length=522) Species: 10090 (Mus musculus) [Search protein sequence]
SHGQSCLGCVVLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYF
LVQTFGSDIIKLLDEAMKADVVCYALEFCKRQCHLYPLPQEAWESALEKA
RQVLRICSLPFLTKICQKIELSIKKAVPFKDVDSDKHSVFPTLRGYHWRG
RDCNDSDKTVYPGRRPDNWDIHQDSNCNGIWGIDPKDGIPYEKKFCEGSQ
PRGIILLGDAAGAHFHIPPEWLTASQMSVNSFLNLPSALTDELNWPQLSG
VTGFLDSTSGIEEKSIYHRLRKRNHCNHRDYQSISKNGASSRNLKNFIES
LSRNQASDHPAIVLYAMIGNDVCNSKADTVPEMTTPEQMYANVMQTLTHL
NSHLPNGSHVILYGLPDGTFLWDSLHNRYHPLGQLNKDVTYAQFFSFLRC
LQLNPCNGWMSSNKTLRTLTSERAEQLSNTLKKIATTETFANFDLFYVDF
AFHEIIEDWQKRGGQPWQLIEPVDGFHPNEVASLLQANRVWEKIQLQWPH
VLGKENPFNSQIEEVFGDQGGH
3D structure
PDB5w7f Crystal structure of the mammalian lipopolysaccharide detoxifier.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.77: acyloxyacyl hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D183 D185 D187 H189 D204 D207 D131 D133 D135 H137 D152 D155
BS02 CA A D185 D187 D204 N206 D209 V212 D133 D135 D152 N154 D157 V160
BS03 CA A D222 D226 N228 N230 I232 E244 D170 D174 N176 N178 I180 E192
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0046872 metal ion binding
GO:0050528 acyloxyacyl hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0008653 lipopolysaccharide metabolic process
GO:0009104 lipopolysaccharide catabolic process
GO:0050728 negative regulation of inflammatory response
Cellular Component
GO:0005576 extracellular region
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5w7f, PDBe:5w7f, PDBj:5w7f
PDBsum5w7f
PubMed29343645
UniProtO35298|AOAH_MOUSE Acyloxyacyl hydrolase (Gene Name=Aoah)

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