Structure of PDB 5w6e Chain A

Receptor sequence
>5w6eA (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]
YSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKI
PTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLS
EIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISS
VFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTA
LQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKE
AELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQVVSF
RSTWVKRIQENKQKWKERAAS
3D structure
PDB5w6e Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H227 H263 D264 D370 H78 H114 D115 D221
BS02 0NY A H223 H373 L388 F392 Q421 F424 H74 H224 L239 F243 Q272 F275 MOAD: ic50=9.1nM
PDBbind-CN: -logKd/Ki=8.04,IC50=9.1nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5w6e, PDBe:5w6e, PDBj:5w6e
PDBsum5w6e
PubMed29718668
UniProtQ01064|PDE1B_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Gene Name=PDE1B)

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