Structure of PDB 5w5j Chain A

Receptor sequence
>5w5jA (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
ALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHILHKARFSYI
LPILGICNEPFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIA
LGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFTIIYMPPENYEPIK
HDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDI
PHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQL
K
3D structure
PDB5w5j Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.
ChainA
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 K148 Q150 N151 D164 T189
Catalytic site (residue number reindexed from 1) D117 K119 Q121 N122 D135 T137
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9WS A V32 A45 V46 K47 L79 I93 T95 M98 L153 V24 A37 V38 K39 L51 I64 T66 M69 L124 PDBbind-CN: -logKd/Ki=5.82,IC50=1.5uM
BindingDB: IC50=1500nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5w5j, PDBe:5w5j, PDBj:5w5j
PDBsum5w5j
PubMed29057049
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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