Structure of PDB 5w5i Chain A

Receptor sequence
>5w5iA (length=430) Species: 9606 (Homo sapiens) [Search protein sequence]
QVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLSVGIHNLLAYVK
HLKGQNEEALKSLKEAENLVRSLVTWGNFAWMYYHMGRLAEAQTYLDKVE
NICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDP
ENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGYIKVL
LALKLQDEGQEAEGEKYIEEALANMTYVFRYAAKFYRRKGSVDKALELLK
KALQETPTSVLLHHQIGLCYKAQMIQEKLDKMIRSAIFHFESAVEKKPTF
EVAHLDLARMYIEAGNHRKAEENFQKLLCMKPVVEETMQDIHFHYGRFQE
FQKKSDVNAIIHYLKAIKIEQASLTRDKSINSLKKLVLRKLRRKALDLES
LSLLGFVYKLEGNMNEALEYYERALRLAAD
3D structure
PDB5w5i Structural insights into IFIT1 dimerization and conformational changes associated with mRNA binding
ChainA
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R38 K151 G154 Y157 R187 G190 F191 A194 Y218 Y252 R255 Y256 K259 R262 L286 H289 Q290 L293 K336 F339 V341 D345 D379 R30 K129 G132 Y135 R165 G168 F169 A172 Y196 Y227 R230 Y231 K234 R237 L261 H264 Q265 L268 K297 F300 V302 D306 D340
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0009615 response to virus
GO:0019060 intracellular transport of viral protein in host cell
GO:0032091 negative regulation of protein binding
GO:0045070 positive regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0051097 negative regulation of helicase activity
GO:0051607 defense response to virus
GO:0051707 response to other organism
GO:0071357 cellular response to type I interferon
GO:0071360 cellular response to exogenous dsRNA
GO:0140374 antiviral innate immune response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043657 host cell

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5w5i, PDBe:5w5i, PDBj:5w5i
PDBsum5w5i
PubMed
UniProtP09914|IFIT1_HUMAN Interferon-induced protein with tetratricopeptide repeats 1 (Gene Name=IFIT1)

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