Structure of PDB 5w4v Chain A

Receptor sequence
>5w4vA (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEM
WERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMC
RAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDE
IALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKL
PPKGKLRSL
3D structure
PDB5w4v 6-Substituted quinolines as ROR gamma t inverse agonists.
ChainA
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9WA A L287 C320 L324 M365 F377 F378 E379 F388 I400 L21 C54 L58 M99 F111 F112 E113 F122 I134 PDBbind-CN: -logKd/Ki=7.15,Kd=70nM
BindingDB: Kd=5.0nM,IC50=89nM
BS02 9WA A M313 W317 M47 W51 PDBbind-CN: -logKd/Ki=7.15,Kd=70nM
BindingDB: Kd=5.0nM,IC50=89nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:5w4v, PDBe:5w4v, PDBj:5w4v
PDBsum5w4v
PubMed29079472
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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