Structure of PDB 5w4r Chain A

Receptor sequence
>5w4rA (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMW
EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVR
MCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSE
DEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA
KLPPKGKLRSLCSQ
3D structure
PDB5w4r 6-Substituted quinolines as ROR gamma t inverse agonists.
ChainA
Resolution3.002 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9WD A C320 H323 M358 M365 V376 F377 F378 E379 I400 F401 C56 H59 M94 M101 V112 F113 F114 E115 I136 F137 PDBbind-CN: -logKd/Ki=7.48,Kd=33nM
BindingDB: Kd=33nM,IC50=46nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:5w4r, PDBe:5w4r, PDBj:5w4r
PDBsum5w4r
PubMed29079472
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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