Structure of PDB 5w4c Chain A

Receptor sequence
>5w4cA (length=356) Species: 235443 (Cryptococcus neoformans var. grubii H99) [Search protein sequence]
FGVREPKRTGEVSKKMHSKVVIIGSGPGGHTAAIYLARANLEPVLYEGML
ANGFAPGGQLTTTTDVENFPGFPEGVTGTEMMDKFRAQSERFGTKIITET
VARVDLSVRPFKYWTEGEEEEHEFMTADTIILATGASAKRLFLPGEETYW
QSGISACAVCDGAVPIFRQKPLAVIGGGDSAAEEATYLTKYGSHVYVLVR
RDELRASKIMAKRLTSHPKVTVLWNTVATEAKGDGEVLTSLTIKNTKTGE
TGDLPVNGLFYAIGHEPATSLVKSQVELDSDGYIKTVPGTSQTSVHGVFA
AGDVQDKKYRQAITSAGSGCIAALEAERLISEEEADDESLQTEDVHVPAE
HYLGTD
3D structure
PDB5w4c Crystal structure of thioredoxin reductase from Cryptococcus neoformans in complex with FAD (FO conformation)
ChainA
Resolution2.255 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.8.1.9: thioredoxin-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A I36 G37 S38 P40 G41 Y59 G61 A64 F67 G71 Q72 L73 T76 N81 V114 T147 G148 G315 D316 R323 Q324 A325 S328 I23 G24 S25 P27 G28 Y46 G48 A51 F54 G58 Q59 L60 T63 N68 V101 T134 G135 G302 D303 R310 Q311 A312 S315
BS02 CA A E112 E129 E131 E99 E116 E118
BS03 FAD A Y365 L366 Y352 L353
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0019430 removal of superoxide radicals
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5w4c, PDBe:5w4c, PDBj:5w4c
PDBsum5w4c
PubMed
UniProtJ9VRX9

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