Structure of PDB 5w3h Chain A

Receptor sequence
>5w3hA (length=440) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
MREVISINVGQAGCQIGNACWELYSLEHGIKPDGHLEDGLSKPKGGEEGF
STFFHETGYGKFVPRAIYVDLEPNVIDEVRNGPYKDLFHPEQLISGKEDA
ANNYARGHYTVGREILGDVLDRIRKLADQCDGLQGFLFTHSLGGGTGSGL
GSLLLEELSAEYGKKSKLEFAVYPAPQVSTSVVEPYNTVLTTHTTLEHAD
CTFMVDNEAIYDMCKRNLDIPRPSFANLNNLIAQVVSSVTASLRFDGSLN
VDLNEFQTNLVPYPRIHFPLVSYSPVLSKSKAFHESNSVSEITNACFEPG
NQMVKCDPRDGKYMATCLLYRGDVVTRDVQRAVEQVKNKKTVQLVDWCPT
GFKIGICYEPPTATPNSQLATVDRAVCMLSNTTSIAEAWKRIDRKFDLMY
AKRAFVHWYVGEGMEEGEFTEAREDLAALERDYIEVGADS
3D structure
PDB5w3h Structural differences between yeast and mammalian microtubules revealed by cryo-EM.
ChainA
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A G10 Q11 A12 Q15 S141 T146 N207 F225 N229 G10 Q11 A12 Q15 S141 T146 N207 F225 N229
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0000280 nuclear division
GO:0007010 cytoskeleton organization
GO:0007017 microtubule-based process
GO:0030473 nuclear migration along microtubule
GO:0045143 homologous chromosome segregation
GO:0098863 nuclear migration by microtubule mediated pushing forces
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0034399 nuclear periphery
GO:0045298 tubulin complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5w3h, PDBe:5w3h, PDBj:5w3h
PDBsum5w3h
PubMed28652389
UniProtP09733|TBA1_YEAST Tubulin alpha-1 chain (Gene Name=TUB1)

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