Structure of PDB 5w2i Chain A

Receptor sequence
>5w2iA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
ILQHPDGTVLKQLQPPPRGPRELEFYNMVYAADCFDGVLLELRKYLPKYY
GIWSPPTAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFASSEKIQQQ
VSKYPLMEEIGFLVLGMRVYHVHSDSYETENQHYGRSLTKETIKDGVSRF
FHNGYCLRKDAVAASIQKIEKILQWFENQKQLNFYASSLLFVYEGSGSGG
EVEVRMIDFAHVFPSNTIDEGYVYGLKHLISVLRSILDN
3D structure
PDB5w2i Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.140: inositol-tetrakisphosphate 5-kinase.
2.7.1.151: inositol-polyphosphate multikinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A I65 K75 P111 E131 D132 V133 D144 L254 I384 D385 I1 K11 P47 E67 D68 V69 D80 L190 I207 D208
BS02 I3P A R82 K160 Q164 K167 Q196 H388 R18 K96 Q100 K103 Q132 H211
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5w2i, PDBe:5w2i, PDBj:5w2i
PDBsum5w2i
PubMed28882892
UniProtQ8NFU5|IPMK_HUMAN Inositol polyphosphate multikinase (Gene Name=IPMK)

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