Structure of PDB 5w21 Chain A

Receptor sequence
>5w21A (length=922) Species: 9606 (Homo sapiens) [Search protein sequence]
EPGDGAQTWARFSRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQH
GKGASIWDTFTHHPPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSI
SWARVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQ
DAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATG
RLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSSH
WINPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPD
FTESEKKFIKGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSWI
DLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGVD
VIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLI
EKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDV
HHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWAL
ILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLL
ARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAGH
NLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPACPFSQKDKEVAER
VLEFDIGWLAEPIFGSGDYPWVMRDWLNQRNNFLLPYFTEDEKKLIQGTF
DFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLNSPSQVAVVPWG
LRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKA
HILDGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSN
GFPGPRFCPEEFTVCTECSFFH
3D structure
PDB5w21 alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.31: beta-glucuronidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D426 C739 D745 D815 D375 C688 D694 D764
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5w21, PDBe:5w21, PDBj:5w21
PDBsum5w21
PubMed29342138
UniProtQ9UEF7|KLOT_HUMAN Klotho (Gene Name=KL)

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